Spi1 macrophage
WebApr 11, 2024 · The transcription factors HIF1A, KLF5, RUNX1, SP1, SPI1, STAT1, MBD1, and WT1 may be involved in the regulatory mechanisms of diabetic nephropathy development. Skip to main content. ... CD48 and CD53 may be involved in humoral immunity and macrophage activation, and integrated polygenic regulation promotes the inflammatory … WebNational Center for Biotechnology Information
Spi1 macrophage
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WebMar 21, 2024 · SPI1 (Spi-1 Proto-Oncogene) is a Protein Coding gene. Diseases associated with SPI1 include Agammaglobulinemia 10, Autosomal Dominant and Erythroleukemia . … WebFeb 7, 2014 · The transcription factor SPI1/PU.1 is a member of the Ets family proteins expressed in myeloid and B lymphoid cells. 8, 9 It has an essential role in the acquisition …
WebJun 5, 2024 · The color intensity denotes the level of confidence of the regulation. (B) Gene-expression analysis by qPCR for Foxo1 (Upper) and Spi1 (Lower) in macrophages (RAW … WebNov 12, 2015 · Salmonella pathogenicity island (SPI) 1 and SPI4-encoded proteins, and other virulence determinants, mediate the entry into epithelial cells [ 4, 6 ]. The bacteria subsequently exit from epithelial cells and are taken up by the phagocytic cells of the innate immune system such as macrophages [ 7, 8 ].
WebNov 12, 2015 · The sopB gene encodes a SPI1-translocated effector and is macrophage down-regulated by 50-fold. In contrast, the gene encoding the SPI2 effector pipB is up … WebApr 25, 2013 · BLaER1 Cells, Derived from the Burkitt Lymphoma Cell Line Seraphina, Can Be Converted into Macrophage-like Cells at High Efficiencies As a prototypic model of a mature B cell lymphoma, we decided to study the Seraphina cell line.
WebJun 11, 2024 · PU.1, encoded by the Spi1 gene, has long been implicated as a key regulator of the cell fate decisions between the myeloid and lymphoid lineages ( 11 – 13 ). PU.1 concentration is highest in myeloid cells where it functions as a pioneer factor to broadly promote lineage-specific gene expression ( 14 ).
WebFeb 14, 2024 · Spi-1 proto-oncogene (SPI1, also known as PU.1), which was first isolated by Moreau-Gcherin et al. ( 5) from Friend hemoglobin disease, is an erythroblast transformation-specific (ETS) family transcription factor. The proto-oncogene SPI1 is located in the p11.22 region of human chromosome 11 ( 6 ). chesapeake controls chesapeake vaWebJul 22, 2010 · Some findings suggest that high SPI1 expression may prevent macrophage migration [76]. Determination of the specific functions of SPI1 in the regulation of … flights tucson to cedar rapids iaWebApr 4, 2024 · SPI1 mediates transcriptional activation of TPX2 and RNF2 to regulate the radiosensitivity of lung squamous cell carcinoma. Cytokine responses to LPS in … flights tucson to ewrWebSPI1 (OF, PU.1, SFPI1, SPI-1, SPI-A) protein expression summary. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell d evelopment. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in … flights tucson to chs arriving todayWebSPI1 (OF, PU.1, SFPI1, SPI-1, SPI-A) protein expression summary. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid … flights tucson to georgetown guyanaWebFeb 20, 2014 · To better understand the complexity of transcriptional regulation after macrophage activation, we next analyzed the transcriptional programs of macrophages activated with 28 different stimuli including pattern recognition receptor ligands, cytokines, and metabolic cues (Figure 1 A). chesapeake convention center job fairWebSep 13, 2024 · The Spi1 mutation in bone marrow-derived macrophages in vitro also did not affect expression of transcripts that indicate the M2-biased phenotype. Thus, myeloid cell … chesapeake coronavirus update