Heparanase英文翻译

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August undefined, 2024

Web10 apr 2024 · ∗ Heparanase is a key mediator of macrophage activation and function in tumorigenesis and cross-talk with the tumor microenvironment. Macrophage Polarization … WebHeparanase (Synonyme: Heparansulfat-Endoglycosidase; Endo-β- D -glucuronidase) ist ein vom Körper gebildetes Enzym, eine Endo glycosidase, die spezifisch Heparansulfat -Ketten von Zelloberflächen- und Basalmembran-Heparansulfat- Proteoglycanen spaltet.

Mammalian heparanase: Gene cloning, expression and …

WebHeparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases WebHeparanase, a mammalian endo-h-d -glucuronidase, capable of partially depolymerizing heparan sulfate chains at a limited number of sites, is thought to help promote cancer … fix bathtub drain clog

Heparanase: From basic research to therapeutic …

Web8 apr 2016 · Heparanase is a multifaceted protein endowed with enzymatic activity, as an endo-β-D-glucuronidase, and nonenzymatic functions. It is responsible for the cleavage … WebHeparanase e rene. Regolazione e ruolo dell'heparanase a livello tubulare e nella nefropatia diabetica. Masola, Valentina 2010 Abstract Heparanase (HPSE) is an interesting player in the arena of proteinuric disease and several investigators proposed that this enzyme is responsible for heparan sulphate (HS) reduction in glomerular basement … WebHeparanase is an endo-β-glucuronidase that cleaves at a limited number of internal sites the glycosaminoglycan heparan sulfate (HS). can liquid nails be used as caulking

Computational design and experimental characterisation of a …

Heparanase - an overview ScienceDirect Topics

Web1 giu 2002 · Heparanase was observed in villous cytotrophoblasts (CT), syncytial trophoblasts (ST) and in intermediate trophoblast cell columns in normal first trimester, molar and ectopic pregnancies. The heparanase protein was preferentially expressed in the endothelium of fetal capillaries, and to a much lesser extent in larger fetal vessels. Web18 ago 2004 · Background: Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane. Expression of the heparanase gene is associated with the invasive, angiogenic, and metastatic potential of diverse malignant tumors and cell lines. fix bathtub caulkedhttp://www.dictall.com/indu/016/0151958D68F.htm can liquid plumber be used on pvc pipes

"Web28 nov 2024 · Heparanase has been viewed as a promising anti-cancer drug target for almost two decades, but no anti-heparanase therapy has yet reached the clinic. This … " - Heparanase英文翻译

Heparanase英文翻译

Heparanase - an overview ScienceDirect Topics

Web28 nov 2024 · Heparanase (HPSE) has been defined as a multitasking protein that exhibits a peculiar enzymatic activity towards HS chains but which simultaneously performs other non-enzymatic functions. Through its enzymatic activity, HPSE catalyzes the cutting of the side chains of heparan sulfate (HS) proteoglycans, thus contributing to the remodeling of … Web30 ago 2024 · Heparanase (HPSE), an endoglycosidase that cleaves heparan sulfate, regulates a variety of biological processes that promote tumor progression. In this study, …

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Web1 gen 2024 · Heparanase, a single functional HS-degrading endoglycosidase, is a mammalian endo-β- d -glucuronidase cleaving HS chains at a limited number of sites. The enzyme is synthesized as a latent 65-kDa precursor that undergoes subsequent proteolytic cleavage, yielding 8-kDa and 50-kDa subunits. These subunits heterodimerize to form a … WebHeparanase (HPSE) is the principal enzyme responsible for extracellular heparan sulfate catabolism and is markedly up-regulated in aggressive cancers. HPSE overactivity degrades HSPGs within the ECM, facilitating metastatic dissemination and releasing mitogens that drive cellular proliferation.

Web即时翻译文本&完整的文档文件。为个人和团队提供准确的翻译。每天有数百万人使用DeepL进行翻译。 Web28 mag 2024 · Heparanase promotes tumor growth in breast tumors. We now evaluated heparanase protein and gene-expression status and investigated its impact on disease-free survival in order to gain better ...

WebHeparanase (HPSE) is the only mammalian enzyme that is known to hydrolyse HS. 7–10 In adults, HPSE is normally expressed at low levels, found only in platelets, immune cells … Web"heparanase hpa" 中文翻譯 : 乙酰肝素酶 "heparan sulfate sulfatase deficiency" 中文翻譯 : 肝硫酸脂酶缺乏 "hepariamine" 中文翻譯 : n-去磺肝素; n-去磺酸基肝素; 去磺酸基肝素 …

WebHeparanase (HPSE) is the only mammalian enzyme that is known to hydrolyse HS. 7–10 In adults, HPSE is normally expressed at low levels, found only in platelets, immune cells and the placenta, 11–13 but increased expression of HPSE has been observed in many disease states, including cancer and Covid-19. 14–16 When overexpressed, HPSE catalyses the …

WebHeparanase is an endoglucuronidase that specifically cleaves HS (as well as heparin), acting on the glycosidic bond of GlcA-GlcNS (Mao et al., 2014; Pikas et al., 1998). … fix bathroom tub leakWeb22 ago 2024 · Heparanase, a member of the carbohydrate-active enzyme (CAZy) GH79 family, is an endo-β-glucuronidase capable of degrading the carbohydrate moiety of … fix bathtub drain leakWeb1 giu 2001 · Heparanases can remove all binding sites from the proteoglycan by cleaving the HS chain from the core protein, or they can destroy specific ligand binding sites by … can liquids cause tooth decayWeb360翻译支持中英深度互译，提供生词释义、权威词典、双语例句等优质英语学习资源，360nmt(神经网络机器翻译)智能加持，更熟悉国人表达习惯！ fix bathtub drain clog mobile homeWeb31 ago 2010 · Heparanase and tumor vascularization The cellular and molecular mechanisms underlying enhanced tumor growth by heparanase are only starting to be revealed. fix bathtub drain leverWeb12 ott 2024 · Heparanase: A Novel Therapeutic Target for the Treatment of Atherosclerosis. Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, … fix bathtube stopper leverHeparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides. Visualizza altro The protein is originally synthesised in an inactive 65 kDa proheparanase form in the golgi apparatus and transferred to late endosomes/lysosomes for transport to the cell-surface. In the lysosome it is proteolytically processed Visualizza altro Heparanase has endoglycosidase activity and cleaves polymeric heparan sulfate molecules at sites which are internal within the polymeric chain. The enzyme degrades the … Visualizza altro • Zcharia E, Metzger S, Chajek-Shaul T, Friedmann Y, Pappo O, Aviv A, Elkin M, Pecker I, Peretz T, Vlodavsky I (2002). "Molecular … Visualizza altro The successful penetration of the endothelial cell layer that lines the interior surface of blood vessels is an important process in the formation of blood borne tumour metastases. Heparan sulfate proteoglycans are major constituents of this layer and … Visualizza altro • Overview of all the structural information available in the PDB for UniProt: Q9Y251 (Heparanase) at the PDBe-KB. Visualizza altro fix bathtub drain suction